How and where to order Ribavirin (Copegus, Rebetol) 100 mg, 200 mg capsules and tablets online on Autoimmune Information Network, Inc. website:
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|Forms:||Ribavirin 100 mg, 200 mg tablets and capsules
|Type:||Ribavirin brand, Copegus generic, Rebetol generic
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Ribavirin (trade names include Copegus, Rebetol, Moderiba, Ribasphere, Ribavin, Ribavirin Teva, Ribazole, Vilona, Viramid, Virazide, Virazole) is an antiviral medication from nucleosides and nucleotides pharmacological group. This medicine is used for the treatment of viral infections, such as chronic hepatitis C, respiratory syncytial virus (RSV), viral hemorrhagic fever infections (Crimean-Congo hemorrhagic fever, Lassa fever, Venezuelan hemorrhagic fever, Hantavirus infection), herpes simplex virus, rabies, canine distemper, cancers, acute myeloid leukemia, and related diseases. It works as guanosine (ribonucleic) analog and nucleoside inhibitor. Rebetol and Copegus stop viral RNA synthesis and viral replication. Ribavirin can be used alone or in combinations with interferon, peginterferon, and other antiviral drugs.
Disoproxil Fumarate, Tenofovir (Viread)
Efavirenz, Emtricitabine, Tenofovir (Atripla)
Emtricitabine, Tenofovir (Truvada)
Lamivudine, Zidovudine (Combivir)
Pharmacological and medical categories:
Agents to treat autoimmune diseases
Anti herpes medicines
Anti rabies pills
Medications for the treatment of fevers
J - Antiinfectives for systemic use
J05 - Antivirals for systemic use
J05A - Direct acting antivirals
J05AP - Antivirals for treatment of HCV infections
J05AP01 - Ribavirin
Rabies - A82
Rabies, unspecified - A82.9
Other mosquito-borne viral fevers - A92
Venezuelan equine fever - A92.2
Arenaviral hemorrhagic fever - A96
Lassa fever - A96.2
Other viral hemorrhagic fevers, not elsewhere classified - A98
Crimean-Congo hemorrhagic fever - A98.0
Unspecified viral hemorrhagic fever - A99
Herpesviral [herpes simplex] infections - B00
Herpes simplex myelitis - B00.82
Chronic viral hepatitis - B18
Chronic viral hepatitis C - B18.2
Other viral diseases, not elsewhere classified - B33
Hantavirus (cardio)-pulmonary syndrome [HPS] [HCPS] - B33.4
Viral agents as the cause of diseases classified elsewhere - B97
Respiratory syncytial virus as the cause of diseases classified elsewhere - B97.4
Neoplasms - C00-D49
Myeloid leukemia - C92
Contact with dog - W54
Indications and usage:
Ribavirin (Copegus, Rebetol) is a nucleoside analogue indicated in combination with interferon alfa-2b (pegylated and nonpegylated) for the treatment of Chronic Hepatitis C (CHC) in patients 3 years of age or older with compensated liver disease.
Patients with the following characteristics are less likely to benefit from re-treatment after failing a course of therapy: previous nonresponse, previous pegylated interferon treatment, significant bridging fibrosis or cirrhosis, and genotype 1 infection.
Dosage and administration:
Ribavirin is administered according to body weight.
Dose reduction or discontinuation is recommended in patients experiencing certain adverse reactions or renal dysfunction.
Dosage forms and strengt:
Copegus (Ribavirin) tablets 100 mg, 200 mg.
Rebetol (Ribavirin) capsules 200 mg.
Rebetol (Ribavirin) oral solution 40 mg per mL.
There is limited experience with overdosage. Acute ingestion of up to 20 g of ribavirin capsules, Intron A ingestion of up to 120 million units, and subcutaneous doses of INTRON A up to 10 times the recommended doses have been reported. Primary effects that have been observed are increased incidence and severity of the adverse reactions related to the therapeutic use of Intron A and Ribavirin (Copegus, Rebetol). However, hepatic enzyme abnormalities, renal failure, hemorrhage, and myocardial infarction have been reported with administration of single subcutaneous doses of Intron A that exceed dosing recommendations.
There is no specific antidote for Intron A or ribavirin overdose, and hemodialysis and peritoneal dialysis are not effective for treatment of overdose of these agents.
Pregnancy and men whose female partners are pregnant
Known hypersensitivity reactions such as Stevens-Johnson syndrome, toxic, epidermal necrolysis, and erythema multiforme to ribavirin or any component of the product
Creatinine clearance less than 50 mL/min
Coadministration of ribavirin with didanosine
Warnings and precautions:
Embryo-fetal toxicity: may cause fetal harm. Patients should have a negative pregnancy test prior to therapy and use effective contraception and undergo periodic pregnancy tests.
Patients exhibiting the following conditions should be closely monitored and may require dose reduction or discontinuation of therapy:
Hemolytic anemia may occur with a significant initial drop in hemoglobin.
Pulmonary infiltrates or pulmonary function impairment.
New or worsening ophthalmologic disorders.
Severe decreases in neutrophil and platelet counts, and hematologic, endocrine (e.g., TSH), and hepatic abnormalities.
Dental/periodontal disorders reported with combination therapy.
Concomitant administration of azathioprine.
Weight loss and growth inhibition reported during combination
therapy in pediatric patients. Long-term growth inhibition (height) reported in some patients.
Monotherapy with ribavirin is not permitted.
Adverse reactions, side effects:
Hemolytic anemia occurred in more than 10% of adult patients receiving Rebetol/PegIntron or Intron A combination therapy.
Most common adverse reactions (40% or greater) in adult patients receiving Copegus or Rebetol/PegIntron or Intron A combination therapy are injection site reaction, fatigue/asthenia, headache, rigors, fevers, nausea, myalgia and anxiety/emotional lability/irritability. Most common adverse reactions (greater than 25%) in pediatric patients receiving Rebetol/PegIntron therapy are: pyrexia, headache, neutropenia, fatigue, anorexia, injection site erythema, and vomiting.
To report suspected side effects of Copegus or Rebetol (Ribavirin) capsules and tablets contact Roche and Merck pharmaceutical companies, or your local FDA.
Nucleoside analogues: closely monitor for toxicities. Discontinue nucleoside reverse transcriptase inhibitors or reduce dose or discontinue interferon, ribavirin or both with worsening toxicities.
Use in specific populations:
Pediatrics: safety and efficacy in patients less than 3 years old have not been established.
Organ transplant recipients: safety and efficacy not studied.
Co-infected patients: safety and efficacy with HIV or HBV co-infection have not been established.
Patient counseling information:
The most common adverse experience occurring with Ribavirin (Copegus, Rebetol) capsules and tablets is anemia, which may be severe. Advise patients that laboratory evaluations are required prior to starting therapy and periodically thereafter. Advise patients to be well hydrated, especially during the initial stages of treatment.
Inform females of reproductive potential and pregnant women that ribavirin pills and oral solution may cause birth defects, miscarriage, and stillbirth. Advise females of reproductive potential that they must have a pregnancy test prior to initiating treatment and periodically during therapy.
Advise females of reproductive potential and male patients with female partners of reproductive potential to use effective contraception during treatment with Copegus or Rebetol and for 6 months post therapy. Advise patients to notify the physician immediately in the event of a pregnancy.
Inform patients that in the event a dose is missed, the missed dose should be taken as soon as possible during the same day. Patients should not double the next dose. Advise patients to contact their healthcare provider if they have questions.
Dental and periodontal disorders
Advise patients to brush their teeth thoroughly twice daily and have regular dental examinations. If vomiting occurs, advise patients to rinse out their mouth thoroughly afterwards.
X - Australia
X - United States (Should not be used during pregnancy)
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
Copegus - Roche
Desiken - Kendrick Laboratorios
Ibavyr - Pendopharm
Moderiba - AbbVie
Rebetol - Schering-Plough, Merck
Ribasphere - Three Rivers Pharmaceuticals
Ribasphere RibaPak Kit - Three Rivers Pharmaceuticals
Ribavin - Lupin Pharmaceuticals
Ribavirin - Arcana Arzneimittel, Cadila Healthcare, CT-Arzneimittel, Generics UK, Hexal, Mylan, Pliva, Sandoz, Teva, Zydus Pharmaceuticals
Ribavirina - Aurobindo, Serral, Teva
Ribavirine - Arrow Generics, Biogaran, Mylan, Ratiopharm, Sandoz, Teva
Ribazole - Getz Pharma, Fair Deal, Getz Brothers Philippines
Robatrol - Roche
Tinamous - Zephyr Pharmatec
Trivorin - Teva, Lemery
Vilona - Valeant Pharmaceuticals, ICN Pharmaceuticals
Vilona Pediatrica - Valeant Pharmaceuticals, ICN Pharmaceuticals
Viracure - Egyptian Pharmaceutical Company, October Pharma
Viramid - ICN Pharmaceuticals, Ilsung Pharmaceuticals
Viramune - Webros Pharmaceuticals
Virazide - Valeant Pharmaceuticals, Armoxindo Farma, Grossman Laboratorios, ICN Pharmaceuticals, Lupin Pharmaceuticals, Novartis, Pharmedic Laboratories, Pinnacle CVS
Virazide Pediatrico - Valeant Pharmaceuticals, Grossman Laboratorios, ICN Pharmaceuticals, Novartis
Virazole - Valeant Pharmaceuticals
Virocid - Ostin Pharmaceutical
Xilopar - Filaxis Laboratorios
Xolox - Ferozsons Laboratoies
APIs used in medicine in combinations with ribavirin:
Interferon Alfa-2b Human recombinant
Interferon Alfa-2b recombinant
Here is a list of popular medications containing ribavirin as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Tablets, Film-Coated; Oral; Ribavirin 200 mgTablets, Film-Coated; Oral; Ribavirin 400 mg
||RocheChugai PharmaceuticalDelphi PharmaceuticalsDKSHEmra-Med ArzneimittelG.A. Stamatis & Co.GenentechHaemato PharmOrifarmPatheon
||Capsules; Oral; Ribavirin 200 mgSolution; Oral; Ribavirin 40 mg / ml
||Schering-PloughAescaAgencia Lei Va HongBayer Schering PharmaEssexFulford PharmaceuticalsMerckPfizerTrading PharmaZuellig Pharma
||Capsules; Oral; Ribavirin 200 mgTablets, Film-Coated; Oral; Ribavirin 200 mgTablets, Film-Coated; Oral; Ribavirin 400 mgTablets, Film-Coated; Oral; Ribavirin 600 mg
||Three Rivers PharmaceuticalsBiomeks IlacDSM PharmaceuticalsKadmon
||Capsules; Oral; Ribavirin 100 mgCapsules; Oral; Ribavirin 200 mgSyrup; Oral; Ribavirin 50 mg / 5 ml
||Lupin PharmaceuticalsPinnacle CVS
||Injectable; Infusion; Ribavirin 100 mg / mlPowder for Solution; Inhalation; Ribavirin 6 g
||Valeant PharmaceuticalsAntigen PharmaceuticalsEgyptian Pharmaceutical CompanyFirma Chun CheongICN PharmaceuticalsIDS GroupInex-IntherexportInvidaJDH PharmaceuticalLegacy PharmaceuticalsMedaOrphan PharmaceuticalSanicoSanofi-AventisUCI-Farma Industria FarmaceuticaViraTekZuellig Pharma
Ribavirin main article on Wikipedia: https://en.wikipedia.org/wiki/Ribavirin
Ribavirin compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Ribavirin
Ribavirin medicine on DrugBank: https://go.drugbank.com/drugs/DB00811
Ribavirin FAQ on MedlinePlus (revised 06/15/2016): https://medlineplus.gov/druginfo/meds/a605018.html
Cadila Ribavirin tablets film coated drug label info on DailyMed (revised September 14, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Aurobindo Ribavirin tablets film coated drug label info on DailyMed (revised November 24, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Zydus Ribavirin capsules drug label info on DailyMed (revised May 15, 2019): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Rebetol (Ribavirin) capsules and liquid drug label info on DailyMed (revised December 1, 2020): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Ribavirin containing drugs on Drugs-About.com: https://drugs-about.com/ing/ribavirin.html
Ribavirin for sale on Pharma Doctor: https://pharma-doctor.com/ribavirin.html
Copegus (Ribavirin) tablets for oral use official prescribing information and medication guide from the U.S. FDA (revised 08/2015): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Rebetol (Ribavirin USP) capsules for oral use, oral solution official prescribing information and medication guide from the U.S. FDA (revised 11/2013): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Copegus (Ribavirin) film-coated tablets prescribing information from Roche pharmaceutical company (revised Jul 2015): https://www.roche.com.sg/content/dam/...
Rebetol (Ribavirin) capsules and oral solution prescribing information from Merck pharmaceutical company (revised 01/2020): https://www.merck.com/product/usa/pi_circulars/r/...
Virazole (Ribavirin for inhalation solution, USP) prescribing information from Bausch & Lomb (revised 05/2019): https://www.bauschhealth.com/Portals/25/Pdf/PI/Virazole-PI.pdf
Ribavirin 200 mg capsules package information leaflet from Medicines.org.uk (revised 09/2020): https://www.medicines.org.uk/emc/files/pil.7117.pdf
Revised: August 2021
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